I like wxPython, which also can be improved (made more Pythonic) by using Hans Nowak's Wax http://www.zephyrfalcon.org/labs/wax.html and also has a great visual framework in PythonCard.
You might check out my links to many Python gui toolkits and related resources at http://www.awaretek.com/plf.html and there's also a podcast for folks who are learning Python ;-))) -- http://mail.python.org/mailman/listinfo/python-list
