if you want something one step simpler than wX & TK take a look at http://www.averdevelopment.com/python/EasyDialogs.html
or http://www.ferg.org/easygui/index.html You loose a lot of flexibility, but get ultra simple (and plain-looking) widgets, without all of the complexity of of a gui Framework, expecially wx. This is a quick and dirty way to add some really simple dialogues to a Python program. But you don't get exposed to the concepts you need to know to work with a full-powered framework. Try PythonCard, for a framework that abstracts wx even further, but still providing most of the functionality (if not all of it) of wx. Alo take a look at QT/pyQT (another framework and it's wrapper) -- http://mail.python.org/mailman/listinfo/python-list