ok, to make this less open-ended, you should mention what O/S and web server you have in mind, whether the web and DB servers will be under your admin (big diff betw python and PHP, as far as finding shared server accounts at web hosts), what kinds of queries, concurrent read/write volumes, transactions, dirtiness, etc. etc Also if you build your questions to this newsgroup on past threads you've read, you will get absolute superb information, I guarantee it.
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