thanks for the comments + help.
i think i got it working, although it's not pretty:
##############################
import os
import re
theRegEx = '.*abs:.*\.*.\\\\'
p = re.compile(theRegEx, re.IGNORECASE)
fileToSearch = 'compreg.dat'
print "File to perform search-and-replace on: " + fileToSearch
print "Using Regex: " + theRegEx
print ""
#set this to an empty string
newdoc = ""
if os.path.isfile( fileToSearch ):
x = open(fileToSearch, "r")
while 1:
line = x.readline()
if(p.match(line)!=None):
print ""
print line
newdoc = newdoc + re.sub("abs:.*\.*.\\\\", "rel:", line)
else: newdoc = newdoc + line
if line == "":
print ""
print "finished !"
break
x.close()
if newdoc != '':
x = open(fileToSearch, "w")
x.write(newdoc)
x.close()
print ""
print "file written!"
raw_input( '\n\nPress Enter to exit...' )
##############################
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