I also had the unresolved externals problem (not the mdir.h problem, though) and my solution was different. a) reinstall correct python2.6.4, using an Intel-flavor msi vice AMD64-flavor b) source the c:\program files(x86\microsoft visual studio 9.0\vc\bin\vcvars32.bat and shazzaaaam the pycrypto build + install worked fine. My CPU is Intel not AMD so I apparently had a bogus python install.
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