Got similar things. Don't know what is the root cause but enabling distribute seems to work...
c:\_work\home>virtualenv --distribute pyve\openpyxl New python executable in pyve\openpyxl\Scripts\python.exe A globally installed setuptools was found (in c:\python25\lib\site- packages) Use the --no-site-packages option to use distribute in the virtualenv. Installing distribute............................................................................................................................................................................................done. Installing pip.................done. c:\_work\home> -- http://mail.python.org/mailman/listinfo/python-list