News123, 20.06.2010 13:12:
Now I have the opportunity to setup a server from scratch.
90% of the content will be non visual content over https with client AND
server certificates.
Access privileges will depend on the client certificate.

I will only have one IP address and only port 443.

1.) What alternatives would exist compared to apache / mod_python
> 5.) What about mod_wsgi vs. mod_python

As others have pointed out, mod_wsgi is preferable over mod_python. In any case, you want your code to run on top of WSGI, as it makes it independent of a specific web server environment (i.e. much more future proof).

I've read happy comments on nginx as an HTTP/S server for WSGI apps, both for being easy to install and set up, and for being fast, versatile and resource friendly. I'd try that before going for an Apache installation.

I'd also second the advice to start with a WSGI setup on top of CGI that's simple to set up, redeploy and test, and then move on to more involved and less agile deployments when you see that you need them.

Stefan

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