It depends on what you want to do. If you still want to beef up on general knowledge, maybe skim through "The Python Cookbook" or something reference-like.
If you feel ready to start doing something with Python, look into one of the recent titles that applies Python for a specific purpose. Examples: "Gray Hat Python" (debugging, reverse engineering) "Natural Language Processing with Python" (pre-order at this time) Any up-to-date (version 1.0 and up) Django book (if you're into Web development) "Expert Python Programming" (best practices) "Beginning Python Visualization" (presenting data visually) "Programming Collective Intelligence" (extracting valuable information from public data sources, and more) Shawn -- http://mail.python.org/mailman/listinfo/python-list