I used to be a wxPython lover, but it was mainly due to the crappy PyQt licensing terms, rather than any merits of wx (although I like the native LnF).
After trying to do a large-ish project using wxPython, I found that I was limited by the lack of widgets and the layout system. My latest project was in PyQt, after Trolltech announced that Qt4 will have a GPL version for Windows (and Riverbank said they will make a PyQt to go with it eventually). I usually hate visual GUI IDEs, but I found QtDesigner to be a real asset, much better than wxDesigner or VisualStudio. The threading implementation also seems superior (easier?) to Python's own too, and making custom widgets is easy enough, even with a Python wrapper. Also, the Cygwin guys have ported the GPL/Linux Qt to Windows, so you can use that for Qt3.3 until Trolltech come up with Qt4. Links: http://kscraft.sourceforge.net/convert_xhtml.php?doc=pyqt-windows-install.xhtml http://kde-cygwin.sourceforge.net/qt3-win32/ http://www.pycs.net/lateral/stories/27.html -- http://mail.python.org/mailman/listinfo/python-list