I'd go with a MySQL / Python / Apache route, but if it's Windows, maybe not.
Also, you shouldn't store images in a database - images should be on the filesystem with their paths stored in the database. I'd definitely say going the web application route would be easier (and more portable) than the GUI route, and a free Windows PyQt is still a long way off, so stick with wxPython if you want a non-web GUI. -- http://mail.python.org/mailman/listinfo/python-list
