Without even checking them all out, I'm thinking the Amara XML Toolkit must be the most feature-packed. The developers are readily available on IRC for support and they seem to make regular releases.
As a meld3 user, I have been using ElementTree under the hood, but was dismayed to find out that you can't find elements by attribute and I am finding it difficult to remove elements. So I am out shopping for a new friend to grok XML. Input welcome. -- http://mail.python.org/mailman/listinfo/python-list