Steve Dower <steve.do...@python.org> added the comment:

> __assume(0) should be replaced with other function, inside the eval 
> switch-case or in the inlined paths of callees. This is critical with PGO.

Out of interest, have you done other experiments confirming this? The reference 
linked is talking about compiler throughput (i.e. how long it takes to 
compile), and while it hints that using __assume(0) may interfere with other 
optimisations, that isn't supported with any detail or analysis in the post.

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue45116>
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