Jason R. Coombs <jar...@jaraco.com> added the comment:

See https://github.com/pypa/setuptools/issues/3007#issuecomment-1068621865 
where I did a brief analysis and probable explanation.

What it boils down to: Setuptools needs to supply its own copy of distutils 
aggressively. It provides an opt out for this behavior and is able to offer 
built in opt out based on whatever signal is available. The default opt out is 
the SETUPTOOLS_USE_DISTUTILS=stdlib env var. for CPython, it also disables the 
behavior when ./pybuilddir.txt is present, but installed Pythons probably don’t 
have this config.

Can those test runners be updated to set this environment variable?

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