Mark Shannon <m...@hotpy.org> added the comment:

Can you reproduce this in pure Python?
If not, can you produce a minimal reproducer using just NumPy?

If you can't do either, I'm going to have to assume that this is a NumPy or 
Pandas bug.

Maybe NumPy or Pandas is accessing CPython internals, but not via the C-API, 
and those internals changed between 3.9 and 3.10?

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nosy: +Mark.Shannon

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<https://bugs.python.org/issue46451>
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