Guido van Rossum <gu...@python.org> added the comment:

So if I understand the speed.python.org results correctly, the time to run 
`python -c pass` went way up, but the time for `python -S -c pass` did not go 
up significantly.

Unfortunately the only machine I have access to is a Mac, and I cannot repro 
this result, using PGO/LTO. Could it be a Linux thing? Or due to something in 
the venv for pyperformance?

Note that I am using a much simpler test script: Tools/scripts/startuptime.py. 
I have not yet succeeded in building and running pyperformance, mostly since 
the Python I build doesn't have SSL configured (I always forget the flag to use 
on my machine) and pyperformance insists on installing a bunch of stuff 
(including new versions of pip and setuptools, it seels).

Can anyone repro the perf regression on their box?

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<https://bugs.python.org/issue46110>
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