Ned Deily <n...@python.org> added the comment:

That is very unusual behavior. Pip has its own private certificate store that 
it uses to make secure connections to pypi.org and the version of pip supplied 
with the python.org 3.10.0 macOS installer should work just fine as is. I just 
verified that it works for me. I'm just guessing here but I think the most 
likely cause of this behavior is that your internet connection is behind a 
misconfigured or malevolent proxy server. You may want to check your DNS 
settings as well to try to use a neutral DNS provider. There are discussions of 
similar problems on the web: try searching for: pypi self signed certificate in 
certificate chain. Good luck!

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue45839>
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