Guido van Rossum <gu...@python.org> added the comment:
I would move "default to "on" (except if actually running out of the source 
tree)" to the "maybe" category. I left a few comments in other deps. I think we 
should start by turning this on by default in PGO builds.

Separately, I encourage you to collect reliable performance numbers. It would 
be nice to see a dip on speed.python.org for this benchmark:

https://speed.python.org/timeline/#/?exe=12&ben=python_startup&env=1&revs=50&equid=off&quarts=on&extr=on

(but that won't show up until we turn this on by default for PGO builds).

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Python tracker <rep...@bugs.python.org>
<https://bugs.python.org/issue45020>
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