Serhiy Storchaka <storchaka+cpyt...@gmail.com> added the comment:

It increases the size of the eval loop. It can break optimizations which is 
performed by the C compiler only when the code size does not exceed some 
limits, and it can exceed the size of processor caches which can make execution 
less efficient. So there are possible negative effects. We should have evidence 
that this change actually improves performance.

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nosy: +serhiy.storchaka

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<https://bugs.python.org/issue40974>
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