Karthikeyan Singaravelan <tir.kar...@gmail.com> added the comment:

Thanks Serhiy, the other issue noted about performance improvement removing 
casefold and I thought re.search per call to be inefficient. My bad that I 
didn't consider the cost of moving the compilation to module level that affects 
import time and about using -X importtime. I agree that the cost is not worthy 
given that regex is used only inside b16decode. I will keep these factors in 
mind when I am doing similar sort of work and try to do a better analysis.

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<https://bugs.python.org/issue35559>
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