Stefan Krah added the comment:

Numpy itself internally doesn't. Consumers of numpy arrays use
memoryviews. Numpy is often used as a library these days, even
for simple things like storing a 2-d table, which can easily be
several TB.

It is also easy to generate unaligned data by just taking a slice
of a bytes memoryview.

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<http://bugs.python.org/issue28055>
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