Kracekumar Ramaraj added the comment:

Updating wheel to latest version fixed assertion issue but uwsgi installation 
still fails.

Virtualenv has updated to latest whhel version 
https://github.com/pypa/virtualenv/blob/develop/virtualenv_support/wheel-0.26.0-py2.py3-none-any.whl.
 Also, my example used `python -m venv`, this is part of stdlib and using 
`pyvenv-3.5` produced same result.

Explicitly setting `CC=clang` in OSX didn't help 
https://gist.github.com/kracekumar/270533354d62be46f77d and also on Ubuntu 
14.04 produces same error with gcc and clang.

I have opened an issue in uwsgi https://github.com/unbit/uwsgi/issues/1100.

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