Jonas Wagner added the comment:

Thanks Ned, this is interesting!

I don't know about Mac OS, but on Ubuntu, LTO and PGO apparently make Python 
around 10% faster (see #17781). However, that data point refers to GCC's LTO, 
not LLVM's.

Personally I'm interested in LTO because I want to obtain whole-program LLVM 
bitcode files (for use in a research project about instrumentation). However, 
if there is something I can help (e.g., running benchmarks with different 
compilation settings), let me know.

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<http://bugs.python.org/issue21122>
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