Thomas Heller added the comment:

I think this is a serious problem (and thanks, amaury, for finding the
spot). comtypes, like ctypes, uses quite a bit of isinstance calls.

It is the reason that the comtypes unit tests run between 8% and 25%
slower with trunk than with python 2.5.1.  If I comment out the code
that you mentioned, python trunk is slightly faster than 2.5.1.  I
suggest to raise the severity.

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nosy: +theller

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