Yury Selivanov added the comment:

I wrote a small micro-benchmark, that creates 100K tasks and executes them.

With debug code the execution time is around 2.8-3.1s, with debug comment 
commented out it's around 2.3-2.4s.

Again, it's a micro-benchmark, and in a real application the impact is going to 
be much smaller.

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<http://bugs.python.org/issue20275>
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