Christian Heimes added the comment:

without abc:
$ time ./python Lib/test/regrtest.py test_decimal
real    0m10.113s
user    0m9.685s
sys     0m0.196s

with numbers.Real subclass:
$ time ./python Lib/test/regrtest.py  test_decimal
real    0m16.232s
user    0m15.241s
sys     0m0.384s

Proposed patch:
$ time ./python Lib/test/regrtest.py  test_decimal
real    0m11.128s
user    0m9.533s
sys     0m0.260s

Only with if instance.__class__ in cls._abc_cache: return True
$ time ./python Lib/test/regrtest.py  test_decimal
real    0m11.201s
user    0m10.345s
sys     0m0.292s

Wow, __instancecheck__ must be called a *lot* of times.

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<http://bugs.python.org/issue1762>
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