R. David Murray <rdmur...@bitdance.com> added the comment:

In general it is difficult to impossible to get Python2 to unload modules 
before the interpreter shuts down.  See issue 9072.  I'm not savvy enough with 
the C stuff to know if the fact that you loaded it via ctypes changes anything, 
but I doubt it.

Note that the implication of that issue is that if you could move to Python3 
there might be a way to do it, but that would indeed be an enhancement as there 
is no direct support for it yet.

----------
nosy: +r.david.murray
versions: +Python 3.3 -Python 2.7

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<http://bugs.python.org/issue14597>
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