There is an opening for a Senior Scientist in the Structural Chemistry
Department at Merck in Boston MA. The job description is posted below. For more
information and to apply, please go to
https://taleo.msd.com/careersection/merck_external_career_section/jobdetail.ftl?job=CHE004532&lang=en&sns_id=mailto
Senior Scientist-CHE004532
Description
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States
and Canada, is a global health care leader with a diversified portfolio of
prescription medicines, vaccines and animal health products. Today, we are
building a new kind of healthcare company – one that is ready to help create a
healthier future for all of us.
Our ability to excel depends on the integrity, knowledge, imagination, skill,
diversity and teamwork of an individual like you. To this end, we strive to
create an environment of mutual respect, encouragement and teamwork. As part
of our global team, you’ll have the opportunity to collaborate with talented
and dedicated colleagues while developing and expanding your career.
This position within the Structural Chemistry Department at Merck Research
Laboratories (Boston MA USA) will support drug lead discovery and optimization
through the experimental structural determination and interpretation of
therapeutically important targets. The successful candidate will perform
crystallization screening, crystal optimization, and structure determination of
ligand complexes and will work in collaboration with medicinal and
computational chemists. The successful candidate will also work closely with
molecular biologists and protein biochemists and will have access to automated
cloning, expression, and crystallization technologies as well as a variety of
instrumentation for biophysical analyses.
Productive and collaborative interactions with other members of the global,
cross-functional department are required. There is an expectation for periodic
travel to other locations. Cooperative and collaborative use of internal
expertise and resources will be essential to success. The position requires
active interaction with the external scientific community to continually
improve scientific understanding, including presentations at national or
international meetings.
Consistently cited as an inspiring place to work, Merck employs talented people
who discover, develop, manufacture, and market a wide range of vaccines and
medicines to address unmet medical needs. Each of us is joined by an
extraordinary sense of purpose bringing Merck’s finest achievements to people
worldwide.
Qualifications
Education :
* Ph.D. degree with minimum of 2 years postdoctoral training in protein
crystallography.
Required :
1. Demonstrated capability to design and execute X-ray crystallographic
structure determination using all modern techniques, including molecular
replacement and experimental phasing.
2. Excellent communication skills (written, presentation, and oral) that
enhance team-based progress is required. Application of those skills both
within and outside the department to ensure understanding of program status for
therapeutic area project teams and management.
3. Demonstrated potential to develop project management skills and
identify/develop new areas of scientific expertise in protein crystallography.
4. Ability to work effectively and flexibly within timelines.
5. Ability to prepare peer-reviewed publications.
Preferred:
1. Knowledge of state-of-the-art structural biology techniques including
construct design, expression, purification, crystallization
screening/optimization, and structure determination/analysis.
2. Experience with biophysical and functional characterization methods (e.g.
SPR, thermal shift and calorimetric assays) to guide construct design and
optimization of solution conditions for successful structural outcomes.
3. Experience with fragment-based lead discovery techniques and workflows.
4. Experience with additional structural techniques such as serial
crystallography, macromolecular NMR, electron microscopy, and small-angle
scattering.
5. Experience crystallizing nucleic acid (especially RNA) and protein:nucleic
acid complexes.
Our employees are the key to our company’s success. We demonstrate our
commitment to our employees by offering a competitive and valuable rewards
program. Our Company’s benefits are designed to support the wide range of
goals, needs and lifestyles of our employees, and many of the people that
matter the most in their lives. If you need an accommodation for the
application process please email us at staffingaa...@merck.com.
Search Firm Representatives Please Read Carefully:
Merck & Co., Inc. is not accepting unsolicited assistance from search firms for
this employment opportunity. Please, no phone calls or emails. All resumes
submitted by search firms to any employee at Merck via email, the Internet or
in any form and/or method without a valid written search agreement in place for
this position will be deemed the sole property of Merck. No fee will be paid
in the event the candidate is hired by Merck as a result of the referral or
through other means.
For more information about personal rights under Equal Employment Opportunity,
visit:
EEOC Poster
<http://www1.eeoc.gov/employers/upload/eeoc_self_print_poster.pdf>
EEOC GINA Supplement
<http://www1.eeoc.gov/employers/upload/eeoc_gina_supplement.pdf>
Merck is an equal opportunity employer, Minority/Female/Disability/Veteran –
proudly embracing diversity in all of its manifestations.
Job
:Chemistry
Job Title:Sr. Scientist, Chemistry
Primary Location
: NA-US-MA-Boston
Employee Status
: Regular
Travel
: Yes, 10 % of the Time
Number of Openings
: 1
Shift (if applicable): 1st
Hazardous Materials: standard biochemistry lab chemicals
Notice: This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from
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