Thank you for the reply and your help, Jonathan. I've answered your 
questions inline.

Oh! Deleting the .pyc files did it. Thank you very much! I remember 
learning about the potential for that problem at a Python Bootcamp, but 
hadn't encountered it before.

I appreciate everyone's help.

On Tuesday, June 30, 2015 at 3:36:29 PM UTC-5, Jonathan Vanasco wrote:
>
> Some possibly dumb questions:
>
> 1. are you failing to start it with the same .ini
>
The two projects have different .ini files specific to each project, though 
they are very similar in their Pyramid setup. 
 

> 2. can you start the failed project using the working virtualenv, and vice 
> versa?
>
Thank you--I hadn't thought to try that. The failed project is failed in 
both virtualenvs, but the working project works in both virtualenvs.
 

> 3. have you tried with a new virtualenv, and comparing?
>
Not yet, but I'll put that on the to-do list. Given what I found with your 
suggestion of running each project in the other's virtualenv, I'm thinking 
the issue is somewhere in the failed project.
 

> 4. have you tried deleting all the .pyc files?  sometimes an old one will 
> somehow get stuck and never regenerate, which can cause odd issues like 
> this.
>

 

> 5. any chance you updated python between creating the virtualenvs?  if you 
> update the interpreter, you usually need to reinstall every package.  
>
 

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