Grafana Agent has a "cluster mode" which will shard targets pick a single 
sender client-side.
This is currently in beta.
https://grafana.com/docs/agent/latest/flow/concepts/clustering/

[disclosure: I work for Grafana Labs]

Bryan

On Friday, 4 November 2022 at 06:57:02 UTC [email protected] wrote:

> We are evaluating using Prometheus agent mode in a highly available manner 
> to forward metrics to a 3rd party remote storage using remote write API.
> We need to have multiple shards and multiple replicas per shard. Our 3rd 
> party remote storage does not handle deduplication on their side.
>
> Could someone point me to different options for metrics deduplication on 
> ingestion?
>
>
>

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