So, reading Alex’s comments and also the definition of the “joke” `setf` here:

On Thu, 27 Jun 2019 10:29 -04:00, Mike wrote:
> https://github.com/picolisp/picolisp/blob/dev/misc/setf.l

informs me that the answer to Bruno’s question is: yes, the concept in fact 
*does* exist in picolisp (by the use of its `set` primitive), rendering such as 
a `setf` entirely unnecessary (and un-idiomatic as well). 

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