I was able to reproduce the problem with rakudo 2016.01.1 on Linux.

It seems to be fixed now (maybe with rakudo commit 241e5e5847):

$ ls -lh 126372.data 
-rw-r--r-- 2 christian christian 48M Apr 11 14:07 126372.data

$ time ./perl6-m -e 'my $content = slurp "126372.data", :bin; say 
$content.elems'
49430132

real    0m0.225s
user    0m0.172s
sys     0m0.048s

$ ./perl6-m --version
This is Rakudo version 2016.03-110-g5bfc8fb built on MoarVM version 
2016.03-104-g10d3971
implementing Perl 6.c.

I'm closing this ticket as 'resolved'.

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