Does anyone know why I otrs would have issues with sending notifications?

Wed Nov 17 17:14:18 2010 notice OTRS-CGI-10 Sent agent 'OwnerUpdate' 
notification to '**[email protected]'.
Wed Nov 17 17:14:18 2010 error OTRS-CGI-10 Can't send message: 550Start mail 
input; end with <CRLF>.<CRLF>

Mik
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