**$Self->{'SendmailModule::Port'} = '80';**
SMTP does not use port 80, you may be able to connect to Exchange via this port but I'm assuming this is via a web browser and using the HTTP protocol.
SMTP uses port 25 by default, try changing this value to 25 and see if that works, you may need to tweak Exchange to allow the server you are hosting OTRS on to relay emails through it.
Steve -- Steven Carr Engineer - Khipu Networks Ltd. [EMAIL PROTECTED] - www.khipu-networks.com Secure - Compliant - Infrastructure Registered Office: Fairfax House, 15 Fulwood Place, London WC1V 6AY Registered in England. Company Number 5218573 Specialist Reseller of the year - CRN Channel Awards 2007
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