> I was trying to compile the openbabel (2.4.1) in my mac. both in bash and 
> tcsh the command Cmake is not found. My goal is to use optimize in pymol, for 
> which I need openbabel. Any pointer to solve this?

Homebrew?
% brew install open-babel

http://brewformulas.org/OpenBabel

Cheers,
-Geoff
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