Dear all, The problem was caused by the size of the dataset, which was just over 10.000 lines (excluding censored lines). Including $SIZES LIM1=20000 fixed the problem for me. I was put on the wrong track because it changed my omega matrix which caused a different error, but the size was the underlying problem.
Best regards, Sebastiaan ________________________________ From: Sébastien Bihorel <[email protected]> Sent: Wednesday, March 18, 2026 2:52 PM To: Sebastiaan Sassen <[email protected]>; [email protected] <[email protected]> Subject: Re: Problem with initial values of the omega matrix with nonmem 7.6 Waarschuwing: Deze e-mail is afkomstig van buiten de organisatie. Klik niet op links en open geen bijlagen, tenzij u de afzender herkent en weet dat de inhoud veilig is. Caution: This email originated from outside of the organization. Do not click links or open attachments unless you recognize the sender and know the content is safe. Did you check if the content of the .ext file at iteration 0 also reflects this rounding issue or if this is just a .lst problem? Regeneron - Internal ________________________________ From: Sebastiaan Sassen <[email protected]> Sent: Wednesday, March 18, 2026 9:50 AM To: Sébastien Bihorel <[email protected]>; [email protected] <[email protected]> Subject: [External] Re: Problem with initial values of the omega matrix with nonmem 7.6 Hi Sebastien, I am use the Pirana PsN toolkit to execute the model but the same thing occurs if I run it directly from command line and without psn. I seems that somehow my omega block gets converted to integers in nm7. 6 for this model. I received Hi Sebastien, I am use the Pirana PsN toolkit to execute the model but the same thing occurs if I run it directly from command line and without psn. I seems that somehow my omega block gets converted to integers in nm7.6 for this model. I received the model from an external party and checked if I saw anything in the model file that causes this to happen, but thus far no success. I was wondering if anyone else ran in to this problem. Best Sebastiaan ________________________________ From: Sébastien Bihorel <[email protected]> Sent: Wednesday, March 18, 2026 2:42 PM To: Sebastiaan Sassen <[email protected]>; [email protected] <[email protected]> Subject: Re: Problem with initial values of the omega matrix with nonmem 7.6 Waarschuwing: Deze e-mail is afkomstig van buiten de organisatie. Klik niet op links en open geen bijlagen, tenzij u de afzender herkent en weet dat de inhoud veilig is. Caution: This email originated from outside of the organization. Do not click links or open attachments unless you recognize the sender and know the content is safe. Hi Out of curiosity, how do you submit your NONMEM jobs (eg, which command)? Sebastien Regeneron - Internal ________________________________ From: [email protected] <[email protected]> on behalf of Sebastiaan Sassen <[email protected]> Sent: Wednesday, March 18, 2026 5:57 AM To: [email protected] <[email protected]> Subject: [External] [NMusers] Problem with initial values of the omega matrix with nonmem 7.6 Dear colleagues, I ran into a problem with the omega matrix in nonmem 7. 6 for a model I received (simple FOCE+I advan3 trans4 nothing special). In the model file it is specified like this (I tried different notations as simple decimals, scientific Dear colleagues, I ran into a problem with the omega matrix in nonmem 7.6 for a model I received (simple FOCE+I advan3 trans4 nothing special). In the model file it is specified like this (I tried different notations as simple decimals, scientific notation etc. to no avail): $OMEGA BLOCK(3) 0.107 ; CL 0.48E-1 0.11 ; V1 0.42E-1 0.56E-1 0.084 ; V2 However, with nonmem 7.6 I get a problem with the initial estimates of omega. If I look at the list file I see that it is due to my omega block, which makes sense as the correlations between these values used as initial values of etas are not valid (outside of -1,1). However, these initial estimates are not the ones I provided. Compare this to the same exact model ran on nonmem 7.4.4. Here the initial omega estimates are as described in the model and it runs well. Even in a clean folder without any files other than the dataset (csv) and the model file (mod). Am I doing something wrong or is this something else? Nonmem 7.6: INITIAL ESTIMATE OF OMEGA HAS A NONZERO BLOCK WHICH IS NUMERICALLY NOT POSITIVE DEFINITE 0INITIAL ESTIMATE OF OMEGA: BLOCK SET NO. BLOCK FIXED 1 NO 0.1000E+01 0.4000E+01 0.1000E+01 0.4000E+01 0.5000E+01 0.8000E+01 Compared to nonmem 7.4.4, which seems to do this correctly: 0INITIAL ESTIMATE OF OMEGA: BLOCK SET NO. BLOCK FIXED 1 NO 0.1070E+00 0.4800E-01 0.1100E+00 0.4200E-01 0.5600E-01 0.8400E-01 Best regards, Sebastiaan ******************************************************************** This e-mail and any attachment hereto, is intended only for use by the addressee(s) named above and may contain legally privileged and/or confidential information. If you are not the intended recipient of this e-mail, any dissemination, distribution or copying of this email, or any attachment hereto, is strictly prohibited. If you receive this email in error please immediately notify me by return electronic mail and permanently delete this email and any attachment hereto, any copy of this e-mail and of any such attachment, and any printout thereof. 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