Dear Colleagues I'm getting an error from NONMEM (7.5.1) when I try to run estimation using NUTS with multiple problems, with a really trivial model (one compartment, 1 and 2 parameters estimated for the two problems) The error is: At line 83 of file Fortran runtime error: Attempting to allocate already allocated variable 'nuts_iparts3'
Runs fine with single problem and with 2 problems, runs fine with METH=COND, METH=BAYES or METH=IMPMAP Seems to crash starting problem #2 The control file is below. Running Window 11, Gfortran Also, if I'm FIXing a parameter (THETA(2) in problem 1), does it make sense to have a prior variance? NMTRAN doesn't complain, and it gives reasonable results. $PROB BASE $INPUT AMT EVID OBNUM ID TIME DV COV1 $DATA Model_dev1.csv IGNORE=@ $SUBS ADVAN1 $ABBR DERIV2=NO $PK V = 1 BASECL = THETA(1) CLFCOV = THETA(2) MU_1 = BASECL*(COV1/100)**CLFCOV CL=DEXP(MU_1+ETA(1)) K = CL/V $ERROR IPRED = F IOBS = IPRED *EXP(ERR(1)) Y=IOBS $THETA (-0.356) ; THETA(1) CLEARANCE (0 FIX) ; THETA(2) CLEARANCE~COV1 $THETAP (-0.356, FIX) (0, FIX) $THETAPV BLOCK(2) FIX VALUES(2,0) $OMEGA (0.1) ;; ETA(1) CL $OMEGAP ;; OMEGA PRIOR (0.135 FIX) $OMEGAPD ;; OMEGA PRIOR DF (5 FIX) $SIGMA (0.05) ;; EPS(1) $SIGMAP ;; SIGMA PRIOR (0.24 FIX) $SIGMAPD FIX ;; SIGMA PRIOR DF 5 FIX $EST METH=NUTS INTER CTYPE=0 $PROB FULL $INPUT AMT EVID OBNUM ID TIME DV COV1 $DATA Model_dev1.csv IGNORE=@ REWIND $THETA (-0.356) ; THETA(1) CLEARANCE (-0.2877) ; THETA(2) CLEARANCE~COV1 $THETAP (-0.356, FIX) (-0.2877, FIX) $THETAPV BLOCK(2) FIX VALUES(2,0) $OMEGA (0.1) ;; ETA(1) CL $OMEGAP ;; OMEGA PRIOR (0.135 FIX) $OMEGAPD ;; OMEGA PRIOR DF (5 FIX) $SIGMA (0.05) ;; EPS(1) $SIGMAP ;; SIGMA PRIOR (0.24 FIX) $SIGMAPD FIX ;; SIGMA PRIOR DF 5 FIX $EST METH=NUTS INTER CTYPE=0 An ideas? Thanks Mark Sale M.D. Vice President Integrated Drug Development [email protected] Remote-Forestville CA Office Hours 9 AM - 5 PM Eastern Time +1 302-516-1684 www.certara.com [Certara Logo] This message (including any attachments) may contain confidential, proprietary, privileged and/or private information. The information is intended to be for the use of the individual or entity designated above. If you are not the intended recipient of this message, please notify the sender immediately, and delete the message and any attachments. Any disclosure, reproduction, distribution or other use of this message or any attachments by an individual or entity other than the intended recipient is prohibited.
