At the Leiden Academic Centre for Drug Research of Leiden University, we are looking for a PhD candidate in Pediatric Clinical Pharmacology.
Key responsibilities Neonatal sepsis is one of the main causes of death in babies born too early and many newborns do not recover from sepsis despite adequate antibiotic treatment. You will study different relevant aspects of neonatal sepsis by using population pharmacokinetic/-dynamic modelling and statistical approaches. You will analyze clinical data, such as inflammatory biomarkers, heart rate, body temperature and metabolomic profiles as well as data of a clinical trial on pentoxifylline, a new drug candidate for the treatment of neonatal sepsis. Our aim will be to increase the understanding of neonatal sepsis through computational modelling and to use this knowledge to improve treatment. This position will be in Leiden but the research will be executed in close cooperation with the Erasmus MC Sophia Children’s Hospital, Rotterdam. Selection criteria •Master degree in pharmacy, (bio)pharmaceutical sciences, (bio)medical sciences or a related discipline; •Experience with quantitative pharmacokinetic-pharmacodynamic concepts and/or computational pharmacology; •Experience and/or affinity with data analysis, biostatistics and clinical trials ; •Experience with modelling software, such as R, NONMEM or SimCYP, is a plus; •Excellent (verbal and written) communication skills in English; •Interested in participating in educational tasks (~20% of the contracted hours); •An independent and creative team player. Our organisation The Faculty of Science is a world-class faculty where staff and students work together in a dynamic international environment. It is a faculty where personal and academic development are top priorities. Our people are committed to expand fundamental knowledge by curiosity and to look beyond the borders of their own discipline; their aim is to benefit science, and to make a contribution to addressing the major societal challenges of the future. The research carried out at the Faculty of Science is very diverse, ranging from mathematics, information science, astronomy, physics, chemistry and bio-pharmaceutical sciences to biology and environmental sciences. The research activities are organised in eight institutes. These institutes offer eight bachelor’s and twelve master’s programmes. The faculty has grown strongly in recent years and now has more than 2.200 staff and almost 4,200 students. We are located at the heart of Leiden’s Bio Science Park, one of Europe’s biggest science parks, where university and business life come together. The Leiden Academic Centre for Drug Research (LACDR) is a leading institute dedicated to world-class research and education in drug discovery and development. LACDR comprises a diverse and international team of approximately 150 researchers. All our PhD students are embedded in the Leiden University Graduate School of Science. Our graduate school offers several PhD training courses at three levels: professional courses, skills training and personal effectiveness. In addition, advanced courses to deepen scientific knowledge are offered by the research school. Terms and conditions We offer a full-time one year term position, after a positive evaluation of the progress of the thesis, personal capabilities and compatibility the appointment, the position will be extended by a further four years. Salary range from €2,325.- to €2,972.- gross per month (pay scale P, in accordance with the Collective Labour Agreement for Dutch Universities). Leiden University offers an attractive benefits package with additional holiday (8%) and end-of-year bonuses (8.3%), training and career development and sabbatical leave. Our individual choices model gives you some freedom to assemble your own set of terms and conditions. Candidates from outside the Netherlands may be eligible for a substantial tax break. Diversity Leiden University is strongly committed to diversity within its community and especially welcomes applications from members of underrepresented groups. Information Enquiries can be made to Swantje Völler, assistant professor, LACDR, Pharmacy, e-mail s.vol...@lacdr.leidenuniv.nl<mailto:s.vol...@lacdr.leidenuniv.nl>. Applications To apply for this vacancy, please send an email to s.vol...@lacdr.leidenuniv.nl. Please ensure that you upload the following additional documents quoting the vacancy number: •Curriculum Vitae; •Motivational letter; •Two references that may be contacted by the LACDR. Only applications received no later than 20 January 2020 can be considered
