Dear all, *The Modeling and Simulation (M&S) group in Clinical Pharmacology department at Genentech* is seeking multiple candidates with diverse quantitative expertise and experience levels in pharmacometrics, artificial intelligence/machine learning, and statistical programming:
*SCIENTIST/SENIOR SCIENTIST, PHARMACOMETRICS* The Ph.D. level scientist will be responsible for the development and implementation of Modeling and Simulation (M&S) strategy, in order to ensure that the right drug is administered to the right patient at the right dosing regimen. The M&S activities include population PK/PD models, disease models, statistical models, PBPK models, QSP models, clinical trial simulations, literature meta-analysis, machine learning/deep learning, and other state of the art quantitative techniques. These will be accomplished by working in close partnership with other scientists in Clinical Pharmacology, Clinical Science, Biostatistics, Preclinical and Translational PK, DMPK, Safety Assessment, Biomarker, Diagnostics, Regulatory, RWD (Real World Data), and other functions on project teams. *Qualified candidate could be responsible to manage a group of employees via direct and/or matrix management system, providing oversight of the strategy and implementation of M&S by other scientists across projects.* *Learn more and apply at this LINK <https://www.gene.com/careers/detail/201902-105931/Scientist-Senior-Scientist-Modeling-and-Simulation-Clinical-Pharmacology>* *SCIENTIST/SENIOR SCIENTIST, ARTIFICIAL INTELLIGENCE* The Ph.D. level scientist should be driven to use artificial intelligence (AI) approaches, including machine learning (ML) and deep learning (DL) methods to advance the clinical development of novel drug candidates. Responsibilities include to apply ML, DL, and other state of art advanced analytics skills, in the context of specific molecule or therapeutic area needs to support clinical trials such as dosing, identification of patterns in drug concentration and responses (biomarker, efficacy, safety), analyzing data and infer model parameters, derive biological/pharmacological insights, and the automation of these analytics tasks, to enable PK/PD characterization, patient selection, biomarker and diagnostic investigation,* in vitro *to clinical translation, and combination therapy identification and optimization. Candidate is also expected to maintain expertise and knowledge of technology trend and artificial intelligence landscape in our industry, assess and identify new opportunities for business objectives. *Learn more and apply at this LINK <https://www.gene.com/careers/detail/201903-106765/Scientist-Senior-Scientist-Artificial-Intelligence-Modeling-and-Simulation-Clinical-Pharmacology>* *SENIOR M&S ANALYST / STATISTICAL PROGRAMMER* We are looking for candidate with rich experience in clinical programming environment with an extensive record of on-the-job success. This B.S. or M.S. level candidate will utilize a variety of analytic software such as SAS or R to integrate PK drug concentration-time measures, pharmacodynamic responses, and clinical safety and efficacy information for M&S analyses. This individual will be accountable for activities including data programming, effective resourcing, efficient operations, timely delivery, quality assurance, and regulatory compliance. Additional responsibilities will include set-up and maintenance of systems for programming, data access, sharing, and storage. He/she will also take the initiative to identify gaps and lead the development of standardization, process optimization, and workflow automation. *Candidate may be responsible to manage employees via direct and/or matrix management, providing oversight of project deliverables as well as team and department initiatives. * *Learn more and apply at this LINK <https://www.gene.com/careers/detail/201902-105414/Senior-Modeling-and-Simulation-Analyst-Senior-Modeling-and-Simulation-Analyst-Project-Lead>* *The Vision of Clinical Pharmacology at Genentech is to provide personalized patient-centric treatment to meet evolving healthcare needs of tomorrow and beyond. We will fulfill this vision by: designing novel clinical trials, replacing clinical trials by virtual modeling, and pioneering analytics at point-of-care.* *MEET US to learn more about Genentech, our works and exciting opportunities at coming conferences - PAGE in Stockholm, Sweden and ACoP in Orlando, FL, USA.* Best, Jin *___________________________________________* *Jin Yan Jin, Ph.D.* *Director and Principal Scientist* *Global Head of Modeling and Simulation (M&S) * * and Ophthalmology Clin Pharm Group Leader* *Clinical PharmacologyGenentech, Inc* *Address: Mail Stop 463A, **1 DNA Way, S**outh San **Francisco**, CA 94080* *Office: 650-467-2198; Mobile: 650-745-6253; Email: **jin....@gene.com <jin....@gene.com>; * *jin...@gene.com* <jin...@gene.com> *Admin: Nicole Haddad <haddad.nic...@gene.com <haddad.nic...@gene.com>* *>, **Ching-Wei (Alyssa) Tung <tung.ching...@gene.com <tung.ching...@gene.com>>)*
