Modeling and simulation (M&S) plays an increasingly important role in drug development at Sanofi. This position is for a modeling scientist, with particular emphasis on disease progression modeling and mechanism-based approaches. The scientist will primarily be responsible for developing and executing M&S strategies related to projects and integrating response to therapeutics in disease progression modeling. Developing relationships with internal and external collaborators will be essential to ensure that modeling meets the strategic needs of the project teams. The primary focus will be on modeling efforts to quantitatively integrate drug exposure, pathway biology, disease physiology, and drug response with longitudinal disease course.
Major Duties & Responsibilities * Directs overall pharmacometric project strategy and coordinates modeling activities across projects. Designs, performs, and oversees pharmacometric analyses using a variety of tools and approaches and in collaboration with internal and external partners; * Creates, advocates, and implements innovative program strategies while maintaining and enhancing technical and drug development expertise; * Interacts with project teams and therapeutic areas to proactively contribute expert input into model development, assuring rapid and effective communication of results; * Possesses in-depth understanding of biology relevant to model development; * Selects and collaborates with external partners/CROs; * Maintains state-of-the art knowledge of relevant modeling approaches and techniques. Formal Education And Experience Required * PhD with a track record of productivity in the areas of pharmacometrics, disease progression modeling, computational biology, or related field, as demonstrated by publications and presentations; * Superb skills in collaboration and communicating both verbal and written technical and non-technical information, as appropriate; * Modeling and computational experience, with excellent hands-on scientific computing and programming skills in a variety of computational tools such as MATLAB, Monolix, NONMEM, Mathematica, R, PFIM, STAN, and excellent working knowledge of Linux and Windows environments. Knowledge And Skills Required * Modeling, pharmacometrics, and computational experience; * Solid understanding of PK and quantitative pharmacology principles; * Knowledge of biological pathways relevant to disease and application to model development (e.g., oncology, rare diseases); * Excellent team work and superb skill in communicating information. Location: Cambridge, MA USA Position number: POS_75091432-0002JC Sanofi US Services, Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. To learn more about this position, contact Christine Veyrat-Follet or Jeff Ming by email at christine.veyrat-fol...@sanofi.com<mailto:christine.veyrat-fol...@sanofi.com> or jeffrey.m...@sanofi.com, or view career opportunities at www.sanofi.us
