Modelling & Simulation Position at AstraZeneca Description: The role is focused on modelling and simulation (M&S) techniques to help drug discovery projects to understand and integrate in-vitro and in-vivo absorption, distribution and metabolism (ADME) properties and pharmacokinetic (PK) and pharmacodynamic (PD) properties, including biomarkers for mechanism of action. The role will be based in Gothenburg, Sweden
Major responsibilities: · Define and deliver the translational quantitative/PKPD strategy for efficacy and target safety, in projects from target identification to life-cycle management. · Identify the appropriate M&S approach (e.g. traditional PKPD modelling, non-linear mixed effects modelling, quantitative systems pharmacology) to deliver the aforementioned. · Design preclinical PKPD studies and report results and interpretations to project teams and internal governance bodies. · In collaboration with key functions (e.g. bioscientists, translational scientists, safety scientists, clinical pharmacology and clinical pharmacometricians) integrate the appropriate data to predict human pharmacokinetics, efficacious drug exposure, human longitudinal response (e.g. biomarker and disease effects), and human dosing regimen. · Contribute to estimation of safety margins and make recommendations and predictions on human efficacious dose and exposure. · Deliver drug-drug interaction (DDI) predictions and risk assessments to project teams. Contribute proactively to an innovative working environment where improvements and new ideas are adopted and freely shared. Continuously display scientific progress externally and internally. Key Deliverables: Deliver the PK, DDI and PKPD elements to project teams within the agreed timelines and to the right quality Requirements: · PhD or equivalent level of experience in mathematical modelling and simulation of PK/PD, biological systems, quantitative systems pharmacology and ideally in a preclinical/translational setting · Specialist in modelling and simulation tools such as Matlab, R, NONMEM, WinNonlin/Phoenix NLME, SimCyp · Experience of defining quantitative modelling strategies across several therapeutic modalities (e.g. small molecules, oligonucleotides, proteins, antibodies) · Track record of ability to meet timelines to pre-specified quality and cost · Understanding of integrative aspects of DMPK and pharmacology/safety aspects of drug discovery and development · Experience in pharmaceutical R&D and experience in operating cross-functionally For further information see below: http://jobs.astrazeneca.com/jobs/details/l1rGOT0000006C-preclinical-and-translational-pk-pkpd-scientist- or contact: rasmus.jansson.lofm...@astrazeneca.com<mailto:rasmus.jansson.lofm...@astrazeneca.com> ________________________________ Confidentiality Notice: This message is private and may contain confidential and proprietary information. If you have received this message in error, please notify us and remove it from your system and note that you must not copy, distribute or take any action in reliance on it. Any unauthorized use or disclosure of the contents of this message is not permitted and may be unlawful.
