Dear all, The Quantitative Pharmacology and Pharmacometrics (QP2) group at Merck is now hiring at 3 levels: Senior Scientist, Associate Principal Scientist, and Principal Scientist. Qualified candidates will be hired at the level commensurate with their experience. We sponsor work visas for qualified candidates. Please see below for job description and forward to potential candidates. Thank you for your consideration.
Location: West Point, PA; Upper Gwynedd, PA; Kenilworth, NJ; Rahway, NJ; Boston, MA. To apply online, please visit http://www.merck.com/careers/ · Senior Scientist, R3 (QUA004740) · Associate Principal Scientist, R4 (QUA004739) · Principal Scientist, R5 (QUA004336) ●Senior Scientist § Description Primary responsibilities of Senior Scientists in Quantitative Pharmacology and Pharmacometrics (QP2) include serving as a representative, or supporting the lead representative, for QP2 on drug development teams; developing and executing PK/PD and Modeling & Simulation (M&S) strategies; and applying functional area knowledge to frame critical drug development questions for optimizing model-based drug development. QP2 scientists apply PK/PD and M&S approaches to design and evaluate clinical and preclinical study data, characterize the kinetics of drug absorption and disposition, assess the dynamics of drug effect, and inform dose selection and go/no-go decisions. Senior Scientists are expected to develop a comprehensive understanding of global regulatory expectations for small molecules and biologics, including support for regulatory documents (INDs, CSRs, CTDs), and agency interactions. The QP2 scientist is a quantitative drug developer with a strong, integrated understanding of the strategic elements of drug development (early through late), and leads the combined efforts of QP2 & the wider Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM). In addition to the responsibilities described above, Senior Scientists demonstrate leadership, communication, and collaboration with QP2 leadership and key functional areas to create an aligned, quantitative framework for impactful decision making on drug development teams. Senior Scientists perform job duties in collaboration with more experienced scientists, and are expected to develop expertise in one or more scientific areas for QP2, including: translational and clinical PK/PD analyses, disease state modeling, clinical trial simulations, clinical outcomes modeling, comparator modeling, absorption/biopharmaceutical modeling, adaptive design, clinical utility indices, translation of biomarkers to clinical outcomes, enrollment modeling, etc. § Qualification A Doctorate OR a minimum 4 years with MS OR 6 with BS of experience in a similar role in pharmaceutical drug development or academia, with a record of increasing responsibility and independence. Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical/biomedical engineering, statistics/biostatistics, computational biology/chemistry or a related field. ●Associate Principal Scientist § Description Primary responsibilities of Associate Principal Scientists in Quantitative Pharmacology and Pharmacometrics (QP2) include serving as an expert representative for QP2 on drug development teams, developing and executing PK/PD and Modeling & Simulation (M&S) strategies, and applying functional area knowledge to frame critical drug development questions for optimizing model-based drug development. QP2 Associate Principal Scientists apply PK/PD and M&S approaches to design and evaluate clinical and preclinical study data, characterize the kinetics of drug absorption and disposition, assess the dynamics of drug effect, and inform dose selection and go/no-go decisions. Associate Principal Scientists also maintain a comprehensive understanding of global regulatory expectations for small molecules and biologics, including authoring regulatory documents (INDs, CSRs, CTDs), and representing QP2 at regulatory meetings. The QP2 scientist is a quantitative drug developer, with a strong, integrated understanding of the strategic elements of drug development (early through late), and leads the combined efforts of QP2 & the wider Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM). In addition to the responsibilities described above, Associate Principal Scientists demonstrate outstanding leadership, communication, and collaboration with key functional areas to create an aligned, quantitative framework for impactful decision making on drug development teams. Associate Principal Scientists perform job duties with independence and minimal supervision relative to less experienced scientists, are capable of supporting or leading drug development programs, and authoring strategic documents. Associate Principal Scientists are expected to have or be developing expertise in one or more scientific areas for QP2, including: translational and clinical PK/PD analyses, disease state modeling, clinical trial simulations, clinical outcomes modeling, comparator modeling, absorption/biopharmaceutical modeling, adaptive design, clinical utility indices, translation of biomarkers to clinical outcomes, enrollment modeling, etc. They are also capable of leveraging this expertise, in collaboration with other PPDM leaders and key functional area partners, to provide scientific/strategic leadership and influence on drug development teams. § Qualification At least 3 years of experience in a similar role in pharmaceutical drug development, with an excellent record of increasing responsibility, independence, and demonstrated impact in driving drug development decisions through application of model-based approaches. PhD, PharmD, or other equivalent degree. Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical/biomedical engineering, computational biology/chemistry or a related field. ●Principal Scientist § Description Primary responsibilities of Principal Scientists in Quantitative Pharmacology and Pharmacometrics (QP2) include serving as an expert representative for QP2 on drug development teams, developing and executing PK/PD and Modeling & Simulation (M&S) strategies, and applying functional area knowledge to frame critical drug development questions for optimizing model-based drug development. QP2 Principal Scientists apply PK/PD and M&S approaches to design and evaluate clinical and preclinical study data, characterize the kinetics of drug absorption and disposition, assess the dynamics of drug effect, and inform dose selection and go/no-go decisions. Principal Scientists also maintain a comprehensive understanding of global regulatory expectations for small molecules and biologics, including authoring regulatory documents (INDs, CSRs, CTDs), and representing QP2 at regulatory meetings. The QP2 scientist is a quantitative drug developer, with a strong, integrated understanding of the strategic elements of drug development (early through late), and leads the combined efforts of QP2 & the wider Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM). In addition to the responsibilities described above, Principal Scientists demonstrate outstanding leadership, communication, and collaboration with key functional areas to create an aligned, quantitative framework for impactful decision making on drug development teams. Principal Scientists perform job duties with a high degree of independence relative to less experienced scientists, are capable of supporting and/or leading more complex drug development programs, author strategic documents, and have responsibility for scientific oversight of staff across the group. Principal Scientists are expected to have or be developing expertise in several key scientific areas for QP2, including: translational and clinical PK/PD analyses, clinical trial simulations, disease state modeling, clinical outcomes modeling, comparator modeling, absorption/biopharmaceutical modeling, adaptive design, clinical utility indices, translation of biomarkers to clinical outcomes, enrollment modeling, etc. They are also capable of leveraging this expertise, in collaboration with other PPDM leaders and key functional area partners, to provide scientific/strategic leadership and influence within QP2 as well as outside the department. § Qualification A minimum of 7 years of experience in a similar role in pharmaceutical drug development, with an exemplary record of increasing responsibility, independence, and demonstrated impact in driving drug development decisions through application of model-based approaches. PhD with a concentration in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical/biomedical engineering, computational biology/chemistry or a related field. Merck Culture: Merck & Co., Inc. Kenilworth, NJ USA, is known as MSD outside the United States and Canada. Our business is preserving and improving human life. We also work to improve animal health. All of our actions must be measured by our success in achieving these goals. We value, above all, our ability to serve everyone who can benefit from the appropriate use of our products and services, thereby providing lasting consumer satisfaction. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.
