With a backend (like php) you are always bound to what the backend can
handle, nginx is just a portal here.
The amount of backends should be balanced with the best balance setting like
leastconn/iphash, ea: http://nginx.org/en/docs/http/load_balancing.html and
also consider Lua for managing/offloading backends.
So its not really a number game but a distribution one.

Posted at Nginx Forum: 
http://forum.nginx.org/read.php?2,254012,254091#msg-254091

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