Имеется аналогичная проблема:
2014/05/03 17:41:45 [error] 1118#0: *2585 upstream prematurely closed
connection while reading response header from upstream, client:
112.123.168.55, server: goodwing.ru, request: "POST /wp-comments-post.php
HTTP/1.0", upstream: "http://xx.xx.xx.xx:80/wp-comments-post.php";, host:
"site.ru", referrer: "http://site.ru/2012/10/28/welcome/#comment-17681


Началось после обновления nginx'а до версии nginx/1.5.12

Posted at Nginx Forum: 
http://forum.nginx.org/read.php?21,249593,249800#msg-249800

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