Just wanted to share that I sent an inquiry to this post months ago because the refreshing of my folders (50k emails, aprox) was very slow due to the encryptation of my home folder. Yesterday I decided to move my folders to a new EXT4 partition (with "noatime,data=writeback,barrier=0,nobh,errors=remount-ro" as fstab options) with no encryptation and now everything goes smooth (just 3 seconds to refresh the All_mail folder). Thanks!
-- jm