Both OpenBSD and Qubes OS don't guarantee
perfect security.
Qubes OS has a different take on security
than OpenBSD. Both have different
advantages and disadvantages.
Physical separation is more expensive
and you need to transport more devices
from place to place.
Qubes OS lets you run mainstream OSes.
OpenBSD is a OS and is a great tool to
get to know Unix-like OSes. It is also
a great environment to practise programming
in C language. See "Developing Software
in a Hostile Environment". There is a
"The J for junk option", pledge(2).