Dear MARMAM community, My co-authors and I are pleased to share our most recent publication titled "First description of a lesion in the upper digestive mucosa associated with a novel gammaherpesvirus in a striped dolphin (Stenella coeruleoalba) stranded in the Western Mediterranean Sea".
You will find the open access publication at the *link*: https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-023-03677-2 *Citation*: Vargas-Castro, I., Crespo-Picazo, J.L., Jiménez Martínez, M.Á. et al. First description of a lesion in the upper digestive mucosa associated with a novel gammaherpesvirus in a striped dolphin (Stenella coeruleoalba) stranded in the Western Mediterranean Sea. BMC Vet Res 19, 118 (2023). https://doi.org/10.1186/s12917-023-03677-2 *Abstract*: *Background*: A wide variety of lesions have been associated with herpesvirus in cetaceans. However, descriptions of herpesvirus infections in the digestive system of cetaceans are scarce. *Case report*: A young female striped dolphin stranded in the Valencian Community (Spain) on the 6th August 2021. The animal showed external macroscopic lesions suggestive of an aggressive interaction with bottlenose dolphins (rake marks in the epidermis). Internally, the main findings included congestion of the central nervous system and multiple, well-defined, whitish, irregularly shaped, proliferative lesions on the oropharyngeal and laryngopharyngeal mucosa. Histopathology revealed lymphoplasmacytic and histiocytic meningoencephalitis, consistent with neuro brucellosis. The oropharyngeal and laryngopharyngeal plaques were comprised histologically of focally extensive epithelial hyperplasia. As part of the health surveillance program tissue samples were tested for cetacean morbillivirus using a real-time reverse transcription-PCR, for Brucella spp. using a real-time PCR, and for herpesvirus using a conventional nested PCR. All samples were negative for cetacean morbillivirus; molecular positivity for Brucella spp. was obtained in pharyngeal tonsils and cerebrospinal fluid; herpesvirus was detected in a proliferative lesion in the upper digestive mucosa. Phylogenetic analysis showed that the herpesvirus sequence was included in the Gammaherpesvirinae subfamily. This novel sequence showed the greatest identity with other Herpesvirus sequences detected in skin, pharyngeal and genital lesions in five different species. *Conclusions*: To the best of the authors’ knowledge, this is the first report of a proliferative lesion in the upper digestive mucosa associated with gammaherpesvirus posititvity in a striped dolphin (Stenella coeruleoalba). Please do not hesitate to contact us for any questions you may have. Kind regards, Ignacio Vargas-Castro *Ignacio Vargas Castro* DVM, PhD Student Viral Immunology and Preventive Medicine Unit (SUAT) VISAVET Health Surveillance Centre & Animal Health Department Universidad Complutense Madrid Av. Puerta de Hierro, s/n. 28040 Madrid. spainignav...@ucm.eswww.sanidadanimal.info <https://www.sanidadanimal.info/en/> This message is private and confidential and it is intended exclusively for the addressee. If you receive this message by mistake, you should not disseminate, distribute or copy this e-mail. Please inform the sender and delete the message and attachments from your system, as it is completely forbidden for you to use this information, according to the current legislation. No confidentiality nor any privilege regarding the information is waived or lost by any mistransmission or malfunction. The personal data herein will be collected in the file "Correoweb", under the ownership of the Vice-Rectorate for Information Technologies, in which those interested may exercise their right to access, rectify, erasure or right to object the contents (article 15-21 of Regulation (EU) 2016/679, General Data Protection Regulation). Before printing this mail please consider whether it is really necessary: the environment is a concern for us all.
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