Hello everyone, My co-authors and I are pleased to announce and share our recent paper titled:
*A Multi-Matrix Metabolomic Approach in Ringed Seals and Beluga Whales to Evaluate Contaminant and Climate-Related Stressors* Simond, A.E., Noël, M., Loseto, L., Houde, M., Kirk, J., Elliott, A., and Brown, T.M. *Abstract* As a high trophic-level species, ringed seals (*Pusa hispida*) and beluga whales (*Delphinapterus leucas*) are particularly vulnerable to elevated concentrations of biomagnifying contaminants, such as polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and mercury (Hg). These species also face climate-change-related impacts which are leading to alterations in their diet and associated contaminant exposure. The metabolomic profile of marine mammal tissues and how it changes to environmental stressors is poorly understood. This study characterizes the profiles of 235 metabolites across plasma, liver, and inner and outer blubber in adult ringed seals and beluga whales and assesses how these profiles change as a consequence of contaminants and dietary changes. In both species, inner and outer blubber were characterized by a greater proportion of lipid classes, whereas the dominant metabolites in liver and plasma were amino acids, carbohydrates, biogenic amines and lysophosphatidylcholines. Several metabolite profiles in ringed seal plasma correlated with δ13C, while metabolite profiles in blubber were affected by hexabromobenzene in ringed seals and PBDEs and Hg in belugas. This study provides insight into inter-matrix similarities and differences across tissues and suggests that plasma and liver are more suitable for studying changes in diet, whereas liver and blubber are more suitable for studying the impacts of contaminants. The paper is open access and can be downloaded here: https://www.mdpi.com/2218-1989/12/9/813 Please contact me at asim...@sfu.ca if you would like a copy of the manuscript or if you have any questions. Best regards, Antoine Simond
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