http://www.littleknownsoftware.com/sigpro/ appears to do this.  I don't know 
anything about it, I just found it via google.

I might be more tempted to use AppleScript   Something like

set Siglist to {}
set list to list & "My first Quote"
set list to list & "my Secon Quote"
set SignatureText  to some item of  Siglist
tell mail to make new outgoing message with body SignatureText 

I am not positive that Body is the right property for the text of an e-mail 
message...
  
Jonathan C. Cohn
jonc...@cox.net



On Mar 2, 2011, at 4:02 PM, louie wrote:

> Hi all,
> Is there a application that will  add a saying to my e-mail signature? This 
> saying should change for every new e-mail.
> Thanks
> louie
> louiem...@wavecable.com
> 
> 
> 
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