Am 26.07.2016 um 23:02 schrieb Roberto Fanciulli:
I installed Visual C++ Redistributable for Visual Studio 2015 and again LyX 2.2.1 too, but the problem is not solved.
OK, then please assure that you have the latest Win 10 including all patches offered by Microsoft's Windows update.
Then (or right now if you like) - uninstall LyX 2.2.1 _completely_ - then reinstall it using this installer: http://ftp.lyx.de/LyX%202.2.1/LyX-221-Installer-2.exe - report back thanks and regards Uwe