My book "Algoritmer og datastrukturer" is now printed! (A book on algorithms, in Norwegian)
Lyx is great for writing books, when the publisher
wants a pdf for printing.
I ended up learning a lot of latex and write my own layout file (heavily adapted koma-script book) to get the style they wanted. This is the one area where Lyx has problems - you can write in a nice structured way, but there is no easy way to set up a particular style. Try using 10.5pt text and a set of font files provided by the publisher, and a list of which text elements have what sizes and fonts. Still, this difficult setup is a one-time job independent of manuscript size. Lyx was great for the writing part, which was most of the work. 288 pages and no crashes. :-)
Helge Hafting